2‐(o‐Tolyl)pyridine as ligand improves the efficiency in ketone directed ortho‐arylation
نویسندگان
چکیده
Herein, we report a ruthenium‐catalyzed ketone directed ortho‐arylation wherein the addition of bidentate NC‐type ligand, most effectively 2‐(o‐tolyl) pyridine, significantly enhances C‐H arylation reaction. Various aryl‐alkyl ketones, including cyclic, aliphatic, and heterocyclic ones, are competent substrates, arylboronic acid esters were used as aryl sources. However, substitution with OMe CF3 in aromatic ring substrates is not tolerated, while such residues on benzoic ester possible. Notably, this study provides valuable insights into ketone‐directed ortho presence pyridine adds additional options for catalyst ligand optimization functionalization.
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2023
ISSN: ['1434-193X', '1099-0690']
DOI: https://doi.org/10.1002/ejoc.202300759