2‐(o‐Tolyl)pyridine as ligand improves the efficiency in ketone directed ortho‐arylation

نویسندگان

چکیده

Herein, we report a ruthenium‐catalyzed ketone directed ortho‐arylation wherein the addition of bidentate NC‐type ligand, most effectively 2‐(o‐tolyl) pyridine, significantly enhances C‐H arylation reaction. Various aryl‐alkyl ketones, including cyclic, aliphatic, and heterocyclic ones, are competent substrates, arylboronic acid esters were used as aryl sources. However, substitution with OMe CF3 in aromatic ring substrates is not tolerated, while such residues on benzoic ester possible. Notably, this study provides valuable insights into ketone‐directed ortho presence pyridine adds additional options for catalyst ligand optimization functionalization.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Melatonin improves spermatogonial stem cells transplantation efficiency in azoospermic mice

Objective(s):Transplantation quality improvement and reduction of cellular damage are important goals that are now considered by researchers. Melatonin is secreted from the pineal gland and some organs such as testes. According to beneficial effects of melatonin (such as its antioxidant and antiapoptotic properties), researchers have proposed that the use of melatonin may improve transplantatio...

متن کامل

Site-directed ligand discovery.

We report a strategy (called "tethering") to discover low molecular weight ligands ( approximately 250 Da) that bind weakly to targeted sites on proteins through an intermediary disulfide tether. A native or engineered cysteine in a protein is allowed to react reversibly with a small library of disulfide-containing molecules ( approximately 1,200 compounds) at concentrations typically used in d...

متن کامل

the significance of conjunction as a cohesive device in teaching writing

the research questions were as follows: 1. is there any relationship between the students concious awareness of the form and implications of the conjuncations and their improvement in using appropriate conjunctions? 2. does students knowledge of the from and the implications of the conjunctions help them to produce more coherent writings. 3. does a comparison between english conjunctions and th...

15 صفحه اول

modernist poetics as reflected in the poetry of selected modernist poets

فن شعر (poetics) که پیش از این به معنای مطالعه ی شعر و شیوه های آن بود در قرن بیستم در مفهوم گسترده به نظریه ی ادبی و مشخصه هایی که سبب پیدایش ادبیات است، اطلاق می شود. نوگرایی (modernism) بیش از آنکه از نقطه نظر زمانی دارای اهمیت باشد، گویای زمینه های فکری و اجتماعی است که تحولاتی بنیادین را در هنر و ادبیات رقم زد. تی. اس. الیوت، تی. ئی. هولم و ازرا پاوند از مهمترین نظریه پردازان نوگرایی هستند...

15 صفحه اول

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: European Journal of Organic Chemistry

سال: 2023

ISSN: ['1434-193X', '1099-0690']

DOI: https://doi.org/10.1002/ejoc.202300759